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Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors. Our findings suggest that O2(-) and NO mediate IR injury-induced chronic pain, and that ROS scavengers administered during the peri-reperfusion period have long-term analgesic effects. Ultrastructural investigations of six neoplasms (four of intestinal and two of cervical epithelium type) confirmed the results found with the light microscope. Blue-gray pigmentation in trunk and extremities in a 71-year-old man. Changing its Phe70 into Leu, however, is sufficient to convert it into a functional IGF binder.
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