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Necrosis of the adrenals may precede the calcification observed in some patients with cholesteryl ester storage disease and in most patients with Wolman disease, an allelic variant due to lysosomal acid lipase deficiency. Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901. Fluvastatin was able to increase dose-dependently eNOS concentration.

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Treatment with glutathione precursor decreases cytokine activity. Clinically Significant Symptom Reduction in Children with Attention-Deficit/Hyperactivity Disorder Treated with Micronutrients: An Open-Label Reversal Design Study. Common indications for MV include respiratory failure, heart failure, drug overdose, and surgery. Quality analysis of patient information on surgical treatment of haemorrhoids on the internet.

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Immunization with Cripto-1 modified by addition of a foreign peptide to overcome T-cell tolerance for self-proteins has the potential to generate an antibody-based immune response that ultimately will block Cripto-1 activity in cancer cells. Can the findings from these studies be used to benefit normally hearing children who are at risk for language delays as a result of limited language environments? Transforming growth factor beta 1 supports autonomous growth of human papillomavirus-immortalized cervical keratinocytes under conditions promoting squamous differentiation.

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Following a significant multivariate rank test, these four validated outcome measures were tested in the order given. The calcium paradox: metabolic, electrophysiological, contractile and ultrastructural characteristics in four species.

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Epidemiology of Hemoglobinopathies in the Huzhou Region, Zhejiang Province, Southeast China. Two halogen derivatives (2-chloromethyl-5-hydroxy-4-pyranone and 6-bromo-5-hydroxy-2-hydroxymethyl-4-pyranone) were found to inhibit DNA, RNA and protein synthesis. A serial automated procedure for the simultaneous detection of proline, hydroxyproline and hydroxylysine in one single sample is pesented. The N and C-terminal fragments of barnase form a native-like complex with restored enzymic activity.

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Pepsin solutions were iodinated at pH 5.0-6.0 until 10-20 per cent of the activity was lost and 1/20 (0.7 per cent) of the saturating amount of iodine had been introduced into the protein molecule. On analysing the 11 different Protein DataBank (PDB) structures of plant thiol proteases, the two invariant water molecules W1 and W2 (W220 and W222 in the template 1PPN structure) were observed to form H-bonds with the O b atom of Asn 175.

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Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities. A total of 6058 men aged 64-81 were recruited to a randomised trial, and 3000 were invited to attend a single screening test.

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Implant quality parameters concentrate on the dose received by the prostate (D90, V100) but not that received by the periprostatic tissue. Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects. Further research may be warranted in atopic patients to fully evaluate the clinical efficacy of AZD1981.

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These included excitatory inputs probably originating in neighboring L-cones and inhibitory long-wavelength inputs probably mediated by L-type horizontal cells. All the strains were inhibited by the extract to varying degrees. Distribution of small- and medium-sized molecules within the genital tract of artificially inseminated gilts. Retinoids in eggs and embryos of birds fed fish from the Great Lakes.

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A number of these reactions participate in the destruction of periradicular tissues. For the broadband response and minimum transducer loading required for a resonance measurement in a small sample, polyvinylidene fluoride (PVDF) piezoelectric film (as thin as 9 microns) is ideally suitable. Simultaneously precise frequency transfer and time synchronization using feed-forward compensation technique via 120 km fiber link. Similarly, the inhibition of acantholysis was not due to dissolution, alteration, or coating of pemphigus antigen on epidermal cells, since the intercellular antibodies in the plasma bound as well to methylprednisolone-treated epidermis as to untreated epidermis. Expression of foxD5a in whole embryos has differential dorsal and ventral effects.

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Even more importantly, the dose rates cover the full range of exposures relevant for radiation protection. Whole-body images and pelvic images were acquired at 60 and 90 minutes after tracer administration. Neurinoma of the recurrent nerve presented a rare diagnosis in thyroid gland surgery. Patients with mucositis often have reductions or breaks imposed on cytotoxic therapy, which may lead to reduced survival. Subsequent investigators confirmed these initial findings, and then extended the application to patients with various primary headache disorders, including migraine.

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Biomicroscopic examination showed that, at 1 week after one or two injections, GABPalpha/beta-treated eyes had significantly less neovascularized corneal area than did eyes treated with the empty vector. Erythroid colony formation in vitro from the marrow of dogs with cyclic hematopoiesis: interrelationship of progenitor cells. Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death. During periodontitis, butyrate as a bacterial metabolite and inflammatory agent is often found in millimolar concentrations in periodontal pockets. Practice-based research networks and their impact on dentistry: creating a pathway for change in the profession.

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Relative to the control group, the performance of the stuttering group was depressed on three procedures--the acoustic reflex amplitude function, Synthetic Identification with Ipsilateral Competing Message, and Staggered Spondaic Word test. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). The prevalence of sleep apnoea and its association with microvascular and macrovascular diseases and glycaemic control are poorly documented in T2DM women. Interference of 2 anionic surface-active agents on the bactericidal activity of some antiseptics Long-term glycemic control is significantly related to both development and progression of retinopathy.

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Done with routine surgical instruments, bimanual pupillary stretching seems to be an easy, safe and effective procedure for enlarging small pupils by an average of 2.7 mm during phacoemulsification, especially in eyes with posterior synechias. 201Tl and 18F-FDG are useful for acute myocardial infarction (MI) assessment. These depth percepts are seen only if the viewing time is brief, less than 2-3 sec, and the spacing between the points is small, less than 5-7 min of arc. The plasma concentration of pirmenol was at a subtherapeutic level and the lymphocyte stimulation test was positive in this patient.

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The research showed that accommodating was the most often used conflict style. Investigations into the structure and function of model compounds play an increasingly important role in elucidating the biological significance of vanadium. IDB should be recommended to select the patients with chronic discogenic low back pain. Logistic regression modelling, adjusted for gender, age, maternal education level and study centre, was used to analyse the association between fatty acid intake and atopic diseases stratified by genotype.

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In contrast, the brain levels of m-TA and m-HPA tended to increase. The assisted reproductive techniques used in dogs have strictly limited utility when compared with other mammals. Quality assurance of rapid on-site evaluation of CT-guided fine-needle aspiration cytology of lung nodules So far, the only known X-linked gene is FLNA, which is associated with the periventricular nodular heterotopia type of Ehlers-Danlos syndrome. However, even more importantly epidemiology cannot tell us that lowering cholesterol or raising HDL cholesterol levels will have more therapeutic benefit than decreasing triglyceride levels.

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The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, termed neurofibromin, which is expressed predominantly in neurons, Schwann cells, oligodendrocytes, and leukocytes. Incremental placement significantly reduced microleakage as compared to the bulk technique, regardless of the restorative system used. The first cases appeared when this ram began breeding, and no cases were observed after replacing it. These observations point to the possibility of using SIV-immunodeficient macaques for study of EBV and other oncogenic and immunosuppressive factors in AIDS-associated lymphomagenesis. Our clinical test and molecular findings converge to indicate that maternal hypovitaminosis D imprints the foetus and alters the susceptibility of the offspring to EAE.

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CMS introduced new pediatric critical care codes and renumbered neonatal and pediatric critical care Current Procedural Terminology (CPT) codes in January 2009. We studied whether we could increase the activity of the embedded IL-21 by designing a chimeric IL-21/IL-4 (ChimIL-21/4) molecule and by introducing amino acid substitutions in the receptor binding domain of IL-21 that were predicted to enhance its binding. Diagnostic imaging of primary hepatic leiomyosarcoma: a case report.

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and the PB and OPB were assayed by high performance liquid chromatography. This study indicates that, also in hamsters, the LLNA is a feasible sensitization test system.

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Comparison with human Bid suggested that mono-/diubiquitylation is a specific feature of xBid. Multiplexed high temperature sensing with sapphire fiber air gap-based extrinsic Fabry-Perot interferometers. Participants identified several covert and subtle ways that practitioners contradict their stated goal of empowerment in their interactions with diabetics.

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Failures to focus attention will affect any task engagement (e.g., at work, in the classroom, when driving). These membrane-surrounded compartments are not synthesized de novo but are bequeathed to daughter cells during cell division. Individuals with autism put a heavy demand on medical services, and prevalence estimates are needed for the planning of such services.

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actinomycetemcomitans is resistant to the bactericidal effect of LL-37, our results offer a rationale for the epidemiological association between LL-37 deficiency and the expansion of oral A. The oxytocinase activity in the blood serum, umbilical blood and homogenates from the placenta and umbilical cord was determined in 34 women in labor subjected to continuous lumbar epidural analgesia with 0.125 per cent bupivacaine and 1:800 000 epinephrine. Our findings suggest that stress protein elevation, rather than the nonspecific effects of thermal or ischemic stress, may be responsible for the myocardial protection seen in this model. The specificities of the endo-beta-galactosidases of Bacteroides fragilis and Escherichia freundii towards linear and branched oligosaccharides of the lacto-N-glycosyl series were investigated using as substrates glycolipids containing (a) linear neolactotetra - or hexaosyl sequences, (b) branched biantennary neolactooctaosyl sequences, and (c) triantennary neolactononaor dodecaglycosyl sequences. Parameter optimization in milling of glass fiber reinforced plastic (GFRP) using DOE-Taguchi method.

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Differences between objective and subjective refractions after radial keratotomy. Cortagine infused into the medial prefrontal cortex attenuates predator-induced defensive behaviors and Fos protein production in selective nuclei of the amygdala in male CD1 mice. One-dimensional electronic fluids are peculiar conducting systems, where the fundamental role of interactions leads to exotic, emergent phenomena, such as spin-charge (spinon-holon) separation.

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The lethality RAV is a measure (on a scale from 0 to 1) of the actual risk reduction associated with the applied protective countermeasures. The systems biology approach, that synthesizes information from biological molecules and networks involved in heart failure progression, leads from the regulatory modules of natriuretic peptide system and RAAS, to a more comprehensive network-based biological system with clinical significance. Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model.

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A multicentre trial of the aldose-reductase inhibitor tolrestat, in patients with symptomatic diabetic peripheral neuropathy. Despite the use of different antiemetic schedules, nausea and emesis are significant problems in patients receiving cyclophosphamide-based chemotherapy. In ordering clinical laboratory tests to confirm a presumptive diagnosis, optometrists will be held to a medical standard of care with respect to the interpretation of results, the prompt communication of results to patients, and the reordering of tests that have produced questionable or incorrect findings. These isolates resulted in smaller population reductions than did E. Additionally, the three-unit MOLED showed high performance for device efficiency with double-structured QD interfacial layers due to the enhanced charge balance and recombination probability.

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Fifty-six young and 29 middle-aged adults who were scheduled for lower abdominal, anorectal or extremity surgery under epidural, sacral or brachial plexus blockades received intravenous analgesic or anaesthetic doses of ketamine, combined with diazepam, immediately before the start of the operation. Analysis using size exclusion chromatography demonstrated that the heat-induced oligomeric dissociation of Hsp16.3 was severely blocked due to highly efficient inter-subunit cross-linkages generated by chemical cross-linking, as well as its chaperone activity being reduced.

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Pediatricians must be aware of the association of glaucoma with certain systemic diseases and congenital ocular abnormalities. However, the longitudinal relaxation time (T1) of GHCc and GHC constructs remained stable. This is a valuable resource for understanding/predicting the stability of proteins, and it can be accessible at http://www.gibk26.bse.kyutech.ac.jp/jouhou/Protherm/protherm.html .

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Western blot analysis of glomeruli from Cfh(-/-) mice demonstrated the presence of iC3b. Multiple clinical factors were predictive of drug-seeking behavior.

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Factors of predictive, prognostic value in endometrial neoplasia are classic clinicopathological correlates, such as cytological and architectural atypia and special variants of adenocarcinoma, as well as the extent of invasion and spread. We describe an epidemic involving the explosive onset and rapid resolution of a constellation of symptoms that sent 17 seventh and eighth grade students and four teachers to the emergency department of a hospital after an apparent toxic gas exposure. pestis under conditions where acetate was provided as the primary carbon and energy source as well as under all conditions in which either form of isocitrate lyase was evident. The changes of islet zinc content occurred mainly on account of insulin-producing cells and in coincidence with glycemia changes.

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Age-related characteristics of neurological disorders in patients with hypertension The influence of other anions including chloride, fluoride and sulphate on the sorption efficiency of nitrate and phosphate was examined.

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Rapid advances in modern gene seeking techniques and the sequence data evolving from related genome research should provide both new targets for drug discovery and new insights into risk factors for many neurological and psychiatric disorders. A quantitative summary of use and a qualitative analysis of usefulness were performed. Protective Effect of Nicotine on Sepsis-Induced Oxidative Multiorgan Damage: Role of Neutrophils.

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Experiments with untreated cultures showed intra-individual variation to mitogen stimulation in female lymphocyte cultures, but a significant correlation between the menstrual cycle and the proliferation kinetics of lymphocytes was not found. Most of the MAb positive cells were found in the middle layers and all were parvalbumin but not calbindin immunoreactive. Matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases expression by tubular epithelia and interstitial fibroblasts in the normal kidney and in fibrosis. The approach relaxes the assumptions and avoids simplifications required by simpler modelling approaches. Outcome measures included patient pain measured by visual analog scale (VAS pain), procedure duration, operator satisfaction, complications, and immediate and delayed response to the injected medication.

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Mean concentrations of serum TG, Chol, LDL, and LDL/HDL and Chol/HDL ratios on the 25th day of Ramadan were significantly lower than those recorded one day before Ramadan and on the 3rd day of Ramadan, and the levels found on the 3rd day of Ramadan were also significantly lower than those recorded one day before Ramadan. To make this possible, it is necessary for the patients, his or her family and the medical staff at the hospital to be aware of the realities and possibilities of palliative care at home. In fact, extraocular circadian phototransduction (EOCP) appears to be a phylogenetic rule for the vast majority of species.

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These nano-scale domains disrupt the optimal raft-dependent clustering of proteins necessary for initial signaling. Evaluation of an inexpensive screening scintigraphic test of gastric emptying. The tumor-promoter, TPA, stimulates growth of human epithelial cells but not that of normal fibroblasts.

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Under these conditions, clomipramine increased SAS-EMG activity only in female rabbits. Spinal nerve block produces sympathetic denervation of the bowel with an increase of regional nutritive blood flow. Purification and characterization of wheat and pine small basic protein substrates for plant calcium-dependent protein kinase. Direct magnetic resonance arthrography, indirect magnetic resonance arthrography, and computed tomography arthrography for rotator cuff lesions and superior labral anterior and posterior tears: state of the art

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The objective of the present study was to evaluate the relationship between clinical outcome and time of day of surgery and experience level of the surgeon. In northern blot analysis on lymphocytes, the secreted alpha (alpha s)-chain gene was well expressed compared with the membrane-bound alpha (alpha m)-chain gene, within 2 weeks after the onset of anaphylactoid purpura. For isoprene, the adducts reach approximately the same concentrations in both species. There was an improvement in the quality of life score for all 12 patients, and no functional degradation in swallowing was observed for 10 patients. In order to ensure aesthetic harmony, the clinician must reproduce numerous anatomical components (e.g., cementoenamel junction, points of concavity, developmental lobes, line angles, incisal edge survey form) in restorations while simultaneously providing sufficient functional integrity.