Orifungal is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Orifungal against these fungi and are safer. Thus, Orifungal remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Orifungal is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Orifungal is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Orifungal has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.
Other names for this medication:
Ketoconazole,
Nizoral,
Akorazol,
Arcolan,
Arcolane,
Asquam,
Biogel,
Clarazole,
Conazol,
Daktagold,
Daktarin,
Dezor,
Diazon,
Dikoven,
Eumicel,
Extina,
Funginoc,
Fungoral,
Ilgem,
Kenazol,
Kenazole,
Ketazol,
Ketokonazol,
Ketolef,
Ketovid,
Ketozal,
Liondox,
Lizovag,
Micoral,
Micosin,
Muzoral,
Mycoderm,
Noell,
Orifungal,
Oronazol,
Panfungol,
Perative,
Phytoral,
Pristinex,
Tiniazol,
Tinuvin,
Xolegel,
Yucomy,
Zoloral,
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Megamox,
Avix,
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