Rifagen is a member of the azole family, which inhibits the synthesis of ergosterol of the fungal cell membrane.10 In vitro, the azoles are fungistatic against Candida species. Rifagen is available as IV and oral formulations. Oral Rifagen is very well absorbed, and the bioavailability is greater than 90%. 11 Studies have shown that Rifagen 400 mg daily and amphotericin B deoxycholate showed similar efficacy as empirical treatment for candidemia in neutropenic and nonneutropenic patients, with Rifagen being associated with fewer side effects.
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