Topamax was first approved in the United States in 1996 for treatment of epilepsy. Topamax has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topamax has high bioavailability and low binding to serum proteins. Salivary Topamax levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topamax in adults from 20–30 h to 12 h. Children typically clear Topamax faster than adults.
Other names for this medication:
Topiramate,
Topamax,
Epitomax,
Letop,
Neutop,
Piramax,
Talopam,
Topamac,
Topictal,
Topigen,
Topilex,
Topimax,
Topina,
Topiramato,
Topirol,
Toplep,
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