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Viraday (Tenofovir)
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Tenofovir

Viraday is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Viraday is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of Viraday, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of Viraday explains the accumulation of the drug in these mitochondria-rich cells. Viraday nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial. Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity. Newer, structurally sim.

Other names for this medication:
Tenofovir, Atripla, Tenvir, Trioday, Truvada, Viraday, Viread,

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Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection. Contrary to the classic view, the motor cortex does not consist of two main areas, primary and supplementary motor areas, but of a mosaic of cortical areas with specific connections and functional properties. These data were analyzed in detail by following the variables through each respiratory cycle. Gonococcal arthritis and endocarditis in a 22-year-old primigravida occurred following a midtrimester threatened abortion.

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