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Recent studies have shown that in addition to its well-established function as an integral membrane protein that oligomerizes to form gap junctions, Cx43 plays other roles that are independent of channel (or perhaps even hemi-channel) formation. During the last decade, however, and due to a rapid methodological development in the life sciences and computing/IT technologies, Systems Biology has evolved from a scientific concept into an independent discipline most competent to tackle key questions of biocomplexity-with the potential to transform medicine and how it will be practiced in the future. Use of mesenteric lymphangiography in a calf with chylothorax and chyloperitoneum. Differentiation of PC12EY cells with nerve growth factor (NGF) did not alter either the number of IGF-I receptors nor their affinity for IGF-I.

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A switched attenuator enables 0-10 mV, 0-100 mV, 0-1 V, and 0-14 V ranges of input to be covered. The conclusion is made that activation of the secretory processes with simultaneous action of the above-mentioned mediatory substances is associated with the participation of corresponding intracellular secondary messengers and start of some cascade reactions. Injections of methylnaloxonium into the amygdala produced a weak withdrawal syndrome, and the nucleus accumbens and medial thalamus were the least sensitive structures. Together, these results show that p55 is required for neutrophil polarization by regulating Akt phosphorylation through a mechanism that is independent of PI3Kgamma activity.

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When coeliac children transferred to a gluten-free diet for 6 months or more, anti-gluten antibody fell much more rapidly in serum than in intestinal fluid. Patient pain relief was assessed through return examinations, telephone interviews, or contact with referring physicians. Details of the operative technique and the functional results are reported. This study investigated the use of fibrin glue and compared its effect with traditional sutures for conjunctival closure in strabismus surgery.

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Only one case of CNS infiltration diagnosed when alive has previously been reported in Japan. The degenerate primers were designed based on the conservative regions of GGPS protein sequences from public databases.

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Our evidence indicates that a related protein, SNAP-24, can substitute for SNAP-25 at the larval stage in SNAP-25 nulls. Image registration is a key step in a great variety of biomedical imaging applications. Erythropoietin receptor activation seems to exert its effect by inhibiting apoptosis rather than by affecting the commitment of erythroid lineage, although the mechanism by which this occurs is as yet unclear. Impedance cardiography was used to estimate cardiac output in 10 men during rest and within 5 s after exercise on a bicycle ergometer, including work up to and including maximal aerobic capacity.

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Duplex scanning and light reflection rheography in the assessment of the severity of short saphenous vein incompetence. Brain mapping was carried out in 50 patients with organic brain lesions (tumors, disturbances of vascular circulation, multiple sclerosis, consequences of brain trauma ets.) The parallelism between the severity of the organic brain lesion and the degree of bioelectrical activity disturbances has been discovered. The nervous system collects information from the outer world by specific senses and from the interior milieu by somatic senses. Ten of the patients were found to have bilateral cystic disease of the kidneys. In conclusion, lindane induces oxidative stress by decreasing the activities of antioxidant enzymes and sialic acid levels in the epididymis thereby causing impaired sperm function.

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Intraoperative monitoring of PBI and TOI at the bilateral buttocks showed significant improvement of both parameters after HA bypass. The mechanism(s) underlying the hyperphosphatemia of lactic acidosis is uncertain. We investigated the expression of IL-17-producing cells in human spontaneous abortion. furnieri females with fully developed ovaries were injected intraperitoneally with four different doses of hCG. Anthracyclines are an important reagent in many chemotherapy regimes for treating a wide range of tumors.

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Insufficient energy and nutrient intake in children with motor disability. On the contrary, in postinfarction patients AT III levels of recovery were still significantly lower than those of baseline, suggesting a reduced ability to restore the original concentration of this physiologic inhibitor. To explore the molecular mechanisms by which ADP exerts its mitogenic effect, we tested the hypothesis that stimulation of DNA synthesis in these renal cells is mediated by activation of protooncogenes.

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Significance and role of radiation studies in complex diagnosis of exogenous allergic alveolitis was diminished in all subjects and FRC showed a progressive rise during rebreathing which was proportional to the resistive load afforded by the artificial resistance. Intravitreal injection of BQ-3020 caused a significant retinal vasoconstriction only at the highest dose (1000 pmole). To compare the total coumarins from dried fruits of Cnidium monnieri (TCCM) and nilestriol (Nil) against osteoporosis.

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A sensitive and selective determination method of chlormezanone in plasma has been divised. In particular, we argue that cortical responses of vestibular stimuli cannot be interpreted in the same way as responses of other sensory modalities. It is therefore preferable that immunotherapy be combined with anti-inflammatory drug therapy in most children with asthma.

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To present the preliminary results of our study comparing the outcomes of trabeculectomy with or without OloGen implant in patients requiring glaucoma surgery for uncontrolled intraocular pressure (IOP). The most affected teeth are lower primary central incisors with the incidence of 1:2000 for natal and 1:3500 for neonatal teeth. These results thus provide the first evidence for a more general role of Ds in Wnt signaling during imaginal development, not only affecting cell polarization but also modulating the response to Wg during the subdivision of the wing disc along its proximodistal (PD) axis. Legislative action increased the number of states with clinic access protection laws to 11. Urine flow-dependence and interspecies variation of the renal reabsorption of sulfanilamide.

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Effects of intravenous bolus injection of nicorandil on renal artery flow velocity assessed by color Doppler ultrasound. Food safety knowledge and food-handling practices, food safety practices during pregnancy, attitudes toward listeriosis brochure, and preferred delivery methods.

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A total expectation score for both conventional and high intensity exercise was calculated, ranging from -2 (very negative expectation) to 2 (very positive expectation). A method for detecting sound using a single step-index multimode fiber is presented. Lack of Myod causes a severe reduction in cranial musculature, ablating most muscles including the protractor pectoralis, a putative cucullaris homologue.

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Therefore, these data suggest that the sexual dimorphic pattern in the expression of VP mRNA in these nuclei of the adult brain is evident early in the development process. When pronounced edema of the optical disk and edema in the macula are present, a systematic application of corticosteroids is necessary. Apolipoprotein A-I, the major protein in mammalian high-density lipoprotein, acts as a cofactor for lecithin-cholesterol acyltransferase during the formation of cholesterol ester and as such, is thought to promote cholesterol efflux from peripheral cells to the liver. SINA elaborates on the development of patient-doctor partnership, self-management, and control of precipitating factors.

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Chronic lower limb ischemia diminishes the quality of life and is associated with a higher risk of limb amputation and cardiovascular mortality. Pretreatment with 500 nM phorbol 12-myristate 13-acetate (PMA) for 22-24 h reduced subsequent FSH and LH release (percentage of total cellular FSH and LH released) in response to 100 nM PMA. High resting sinus heart rate and first degree AV block are easily recognized and commonly encountered findings in a cardiology practice. It was the objective of this work to evaluate the effect of high pressure homogenization on the activity of antimicrobial enzymes such as lysozyme and lactoperoxidase against a selected group of Gram positive and Gram negative species inoculated in skim milk. A close relationship between metabolic carotenemia and biliary dyskinesia was strongly suggested.

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Existing applications of ORA have been largely limited to pre-defined terminologies such as GO and KEGG. A non-suppressed ion chromatographic method with conductometric detection is described for the simultaneous determination of six inorganic anions: fluoride, chloride, nitrite, bromide, nitrate and sulphate. into animals, serum creatinine (Cr) and blood urea nitrogen (BUN) reached a peak after 4 days and returned to the initial levels within two weeks. Observations with the Charing Cross Amyotrophic Lateral Sclerosis Rating Scales.

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Plerixafor has been successfully used in clinical trails in patients with malignant lymphoma and multiple myeloma, where mobilization of stem cells with granulocyte colony-stimulating factor for leukapheresis and later stem cell transplantation were not possible. Directional selection on critical photoperiod during the northward divergence of W. Strategy-making capability and performance of Slovak acute hospitals.

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The causative agent was a fastidious, slow-growing, unclassified, gram-negative bacterium, DF-2 (decarboxylase fermenter-2), apparently transmitted by a dog bite. A comparison was made on new cardiovascular events (mean follow up: 2.5 years) between patients with no, incident, and non-incident post-MI depression by survival analysis. Epidemiological survey and analysis on an outbreak of gastroenteritis due to water contamination. Immunocytochemistry analysis using electron microscopy showed that metacyclin-II is localized mainly at the kinetoplast whereas metacyclin-III is localized at the nucleus of the parasite.

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The influence of the method used to introduce the AuNPs (trapping or cogeneration) was not so important. The genomic DNA was extracted from the trypanosomes, and the specific fragment of Trypanosoma 18S rRNA gene was amplified using PCR.

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Kaolin intake induced by apomorphine (10 mg/kg) was inhibited by domperidone (2 mg/kg) and diphenidol (30 mg/kg), but not by diphenhydramine or ondansetron. Moreover, the isolates of the genera Halomonas and Bacillus were shown to be effective in treating very heavily polluted black liquor. Furthermore, point mutations affecting the integrity of the conserved L-X-S-L-F-G motif of p6(gag) completely abolish the interaction between Vpr and the Pr55(gag) and, as a consequence, prevent Vpr virion incorporation. Grain density differences, resulting from the various chase periods, suggested the renewal of the testicular hyaluronidase-sensitive fraction. Whether the time constant of remodelling is similar or not in the heart and large vessels remains an important question that requires further investigation.

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Collodion membranes of high polarizability and low resistance can be obtained either by addition of certain ether-soluble substances such as phosphatides, olive oil, mastix, and gum benzoin, to the collodion or by drying collodion membranes for a limited time under pressure. We present a case of 56-year-old with intraoperative findings of two separate tears in the same corpus cavernosum.

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Crossed immunoelectrophoresis and electroimmunoassay of human IgG subclasses. Screening for impaired glucose tolerance in obese children and adolescents: a validation and implementation study.

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While several mechanisms may be biologically plausible, none of the theories have been tested in clinical trials. Shorter delays resulted in full or partial (less than 6 ova) ovulation. Age-related decrease of plasma testosterone in SAMP8 mice: replacement improves age-related impairment of learning and memory.

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Particularly because the risk of harm cannot be safely excluded, the use of phosphate binders in chronic kidney disease (CKD) patients demands caution. Dedicated CBT group treatment for insomnia improves sleep more than treating sleep as an adjunct to other mental health treatment. T-cell receptors (TCRs) have emerged as a new class of therapeutics, most prominently for cancer where they are the key components of new cellular therapies as well as soluble biologics. Human sural nerve biopsies obtained from diabetic neuropathic patients undergoing treatment with an aldose reductase inhibitor revealed a reduction in intermediates of the polyol pathway.

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We reasoned that key events responsible for this phenomenon might be mediated by Gpbar1, a recently identified and widely expressed G-protein-coupled, cell surface bile acid receptor. Australian physicians may encounter a number of tropical skin diseases. Histological and ultrastructural examination of the liver, GPT, GOT, LDH enzymatic activities, and toxicological mercury evaluation were performed. The implications and limitations of this correlation are discussed.

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Also, the PTZ combination rescued the allogeneic mice from the risk of adverse (tumor-enhancing) effects of CY at moderate doses (25-50 mg/kg) given therapeutically. Separation of plasma lipoproteins in the preparative ultracentrifuge. Cancer patients with a partial response or stable disease revealed a significantly higher increase of cleaved CK-18 during chemotherapy as compared to patients with progressive disease.

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Blood and lymph node aspirates were collected from the infected goats and control goat at intervals, and tissues were also collected from a fetus that was aborted and a doe that died during the trial. Systematic review of the articles about therapeutic management of ADHD with methylphenidate published in secondary and primary publications and critical appraisal by means of methodology of the Evidence-Based Medicine Working Group. Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL.

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The eyes did not tolerate contact lenses at all or because of peripheral location of the keratoconus. Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain. Role of angiotensin receptor blockers in diabetes: implications of recent clinical trials.

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The infusion was given as a bolus and then continuously for 14 hr by radial artery access with two selective kissing catheters. Proteins in the entire region from pH 7.0 to 9.0 with molecular weights (Mr) ranging from 35,000 to 41,000 and a protein focusing from pH 5.2 to 5.3 with Mr of 55,000 were strikingly reduced in MSS. Cuff-radiography could show the site and degree of the dilatation of trachea.

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Purulent maxillary sinusitis developed in 4 of 10 two-week phenylephrine group, 6 of 10 four-week phenylephrine group, 1 of 10 two-week oxymetazoline group and 3 of 10 four-week oxymetazoline group. A gene, encoding the major secreted fibrinolytic protein of Bacillus amyloliquefaciens CH86-1, was cloned from the genomic DNA.

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Detraining of exercise-trained rats: effects on energetic efficiency and brown adipose tissue thermogenesis. Ankylosing spondylitis: defining disease status and the relationship between radiology, metrology, disease activity, function, and outcome. Similarly the serum iron, percentage saturation of transferrin and red cell ferritin were comparable. While the total number of hydrogen bonds is only slightly reduced relative to that found in pure water, we find that hydrogen bonds that form with polyols tend to be less linear than hydrogen bonds formed between water molecules. Application of on-line and off-line heart-cutting LC in determination of secondary metabolites from the flowers of Lonicera caerulea cultivar varieties.

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When brain blow data are difficult to interpret because of reflux, the authors suggest that radiotracer be administered intravenously during inspiration. Effects of age and hearing sensitivity on the use of prosodic information in spoken word recognition. To understand how these DNA lesions are repaired, bleomycin-hypersensitive mutants were isolated from the yeast Saccharomyces cerevisiae.

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The results are encouraging, but there is concern for the moment because of the few studies, so to date there is little data on the subject including medium and long term. The most frequently observed components of MS in the studied sample were AO and HTN. HRP-positive fibers were also observed in the red pulp and in the trabeculae. They also summarized all systematic reviews and synthesized the sparse clinical studies to provide diagnostic recommendations, treatment options, and strategies for prevention. In addition, the amino acid sequences of the two howler monkey pigments show similarities to the pigments encoded by the polymorphic gene of other New World primates.

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Co-existence of superficial brachio-ulno-radial arterial pattern and persistent median artery. The identification of Antirrhinum majus mutants with ectopic petal spurs suggested that petal-spur development is dependent on the expression of KNOTTED 1-like homeobox (KNOX) genes, which are better known for their role in maintaining the shoot apical meristem. These findings suggest the existence of an attention-distractibility trait that confers vulnerability to irrelevant distraction, which can be remedied by increasing the level of perceptual load during the task.

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Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Tc99m-pertechnetate is used as an alternative to I123 in imaging of the thyroid and is generally imaged with gamma cameras or single photon emission tomography instruments. Relationship of risk factors for atherosclerosis to arterial thrombosis. Programmatic strategies aimed at reducing STDs through encouraging responsible sexual behavior would potentially benefit from also including a component that addresses sexual victimization. We theorized that shifting the target of RF coagulation to the facet joint capsule would provide an easier target and a longer-lived pain relieving response.