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Clinical trials of nanotechnology medical products present complex risk management challenges that involve many uncertainties and important risk-risk trade-offs. Emerging role of multi-detector computed tomography in the diagnosis of hematuria following percutaneous nephrolithotomy: A case scenario. Tasks were timed, rated as completed successfully or not, and were subsequently judged subjectively by the participants. Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy.

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Neurons of dorsal root ganglia were immunoreactive but the neurons of the spinal cord were unstained. The aim of this study was to examine the relations between perceived organizational support, the quality of leader-member exchange, in-role and extra-role behaviour, professional identification and organizational identification among registered nurses and nurse assistants. They were randomly assigned into three groups of equal number receiving daily oral capsules containing lemon or sour orange powder or placebo.

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CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality. To study features of specific immunity in patients with diphtheria using data from clinic as well as from animal experiments.

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The anatomical appearances of the valvular lesions were very unusual and suggest a new anatomo-clinical form of the classical Libman-Sacks endocarditis. Association analysis of genetic polymorphisms in the CDC2 gene with late-onset Alzheimer disease. Collagen has an important structural function in several organs of the body, especially in bone and cartilage. The mechanism of anti-epileptic action of VNS that has been hypothesized in the article is found to conform to observations and results in a large number of studies including those on VNS itself.

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Nafazatrom inhibits the hydroperoxide-dependent oxidation of phenylbutazone, stimulates the reduction of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, and is oxidized by microsomal or purified enzyme preparations from ram seminal vesicles. It is shown that this gene is upregulated in diseased tomato plants infected with citrus exocortis viroid.

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The majority of PEM fellowship program directors value the role of HFS in augmenting clinical experience and documenting procedural skills. The drug interaction between methamphetamine and quinidine/cimetidine was investigated in terms of distribution of methamphetamine to the brain. Do laboratory tests allow prediction of coronary vein bypass patency?

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In humans with hypercholesterolemia and increased serum concentration of triacylglycerols no significant changes in activity of alpha-1-antitrypsin and alpha-2-macroglobulin were found--in comparison with control subjects. The addition of a nasal mucosal flap to this technique may aid in proper fistulization and should be studied in larger prospective trials. These results suggest that immature rats are more susceptible for the stress than young mature rats, and application of mature rats to the A-S experiment appears to be available in the case of utilizing A-S rats as the stress ulcer model. The operation should be done only in case of adequate indication. In addition, many pharmaceuticals are relatively hydrophilic, polar, or charged compounds.

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Simultaneous real-time visualization of the vascular anatomy and interventional instruments was achieved under real-time conditions and allowed correct placement of IVC filters in all five cases as confirmed by radiographic angiography. CCK gene and protein expression levels in the different gut segments were measured 3 h and 72 h after feeding, by quantitative real-time RT-PCR and Western blot, respectively. Blue light and UVB light induction experiments using red light- and dark-grown seedlings showed that the flavonoid biosynthetic genes are induced most effectively by UVB light and that blue light induction is mediated by a specific blue light receptor. For flood control purpose, the water level of the Three Gorges Reservoir (TGR) varies significantly.

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Especially relevant is the apparent paradox that gamma/delta T cells play both pro-inflammatory and antiinflammatory roles in response to infection. Effect of cerebral ganglia and dorsal bodies on DNA synthesis induced by heat in the ovotestis of hibernating Helix aspersa Recent advances in understanding signal transduction pathways in worms and flies. This appears to occur in several diseases, including those of the cardiovascular system, where apoptosis plays a key role in atherosclerosis and restenosis following angioplasty. Before solvent extraction, plasma samples are saturated with sodium chloride and made alkaline.

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Validation of the method revealed good recoveries, precision and accuracy. Since glucose transport has been shown to be rate limiting for glucose utilization in muscle in IDDM, these results suggest impaired translocation or activation of glucose transporters in IDDM.

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The prevailing urinary metabolites in humans were the monohydroxylated forms, while N-dealkylated and N-dealkyl monohydroxylated forms were found in rats. H-reflex latency (H-RL) and H/M ratio were measured in normal children and children with paralytic poliomyelitis of 1-3 years of age. The H6D variant was more potent than the WT NAG-1 and inhibited tumor growth significantly compared to control mice.

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Based on structure-activity relationships and in silico MRSA PK binding analysis of these bisindole alkaloids, the authors designed new hamacanthin B derivatives and evaluated their antibacterial activities against drug-resistant pathogens. Proteoglycan monomer predominated in discolored, fibrillated, and osteophytic OA cartilage in peak I. Thus, endogenous granules could serve as non-invasive probes for microtubule network dynamics in mammalian cells. Association between self-efficacy, career interest and rural career intent in Australian medical students with rural clinical school experience.

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These early results indicate an advantage to both patient and hospitals from this approach. Synchronization from second order network connectivity statistics. Linkages which already exist can serve as models for future linkages. Prevalence studies of Japanese cedar pollinosis in densely planted areas were performed using pollen counts, patient studies, and population surveys with questionnaires.

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Our findings are discussed from the view that a cascade of events including acute phase proteins and activated microglial cells are involved in classical amyloid plaque formation. However, the cervical spine FRP has not been investigated extensively, and the speed of movement and loading effects remains to be characterized.

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The case was a 54-year-old man after orthotopic heart transplantation with infected pseudoaneurysm of the ascending aorta. Although observed during the short term, the recurrence-free survival for gemcitabine and carboplatin was comparable to that for methotrexate, vinblastine, doxorubicin and cisplatin. Poisson and logistic regression analyses were used to do multivariable analysis. There has been considerable evidence in vivo, including clinical observations, that abnormal angiogenesis is implicated in a number of disease conditions, which include rheumatoid arthritis, inflammation, cancer, psoriasis, degenerative eye conditions and others.

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Zidovudine (AZT) is an antiretroviral drug widely used in the treatment of human immunodeficiency virus (HIV)-infected patients, whose prolonged administration was found to cause toxic lesions in cardiomyocytes in humans and experimental animals. of zoonotic importance, such as D.immitis, D.tenuis, D.ursi, reviews of human cases were often published. In addition, the release of the antimycotic drug enilconazole from a smedds was investigated as well in order to study the influence of the type of incorporated drug on oil digestion.

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Not all pseudomembranous colitis is caused by Clostridium difficile. -The prophylactic use of Neo-Plasmagel in orthopaedic patients is therefore dependent on a sufficient blockade of histamine receptors. By analyzing heavy metal and oxidative stress sensitivities of the coelomocyte-deficient C.

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Specialized help to women with a risk of hemorrhage during pregnancy and labor ChIP assays demonstrate that BRCA1 is recruited to the promoters of KRT5, KRT17 and CDH3, and re-ChIP assays confirm that BRCA1 is recruited independently to form c-Myc and Sp1 complexes on the CDH3 promoter. It is a difficult task for a diagnostician and it requires experience, close cooperation with a clinician and knowledge concerning surgical techniques. These results indicate that both MISO and 0063 may be combined with conventional therapeutic agents, in this particular case a nitrosourea, to produce an enhanced tumour response.

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We investigate the pattern of particle distribution and its evolution with time in multiparticle systems using the model of random walks with memory enhancement and decay. Two experiments compared the potency of continuous infusions of cholecystokinin octapeptide (CCK-8) for reducing sucrose intake when administered into abdominal arteries or the jugular vein.

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De novo p.Arg756Cys mutation of ATP1A3 causes an atypical form of alternating hemiplegia of childhood with prolonged paralysis and choreoathetosis. Reinstatement of an extinguished fear conditioned response in infant rats. Therefore, this colorimetric approach affords simplicity, sensitivity and reliability in telomerase activity detection.

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By sudden controlled inflation of the inner bag at end inspiration, partial expiratory flow-volume curves were generated and recorded by means of a face mask and pneumotachograph. Subcortical connections of visual areas MST and FST in macaques.

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Vaccines for preventing enterotoxigenic Escherichia coli (ETEC) diarrhoea. Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery disease. However the effects of altered cortisol levels remain poorly understood in the complex context of conduct disorder, callous-unemotional (CU) personality traits, and frequent comorbidities, such as attention deficit hyperactivity disorder (ADHD).

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Microphotography was one of the earliest applications of photography in science. Two of the five horses were sound at the conclusion of the study and one horse, although lame after flexion, was considered by the owner to have been treated successfully. In spite of the results being frequently unfavourable, a general rejection of the operation does not seem to be justified.

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Newly discovered reefs in the southern Abrolhos Bank, Brazil: Anthropogenic impacts and urgent conservation needs. In contrast, adenylyl cyclase stimulation by the asparagine-69 mutant was elicited only by acetylcholine and carbachol but not by oxotremorine M.

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The localization of cytosolic Hsp70s in the stroma of chloroplasts or different mitochondrial compartments could not be observed. Preliminary analysis on morphological characteristics of traditional Chinese medicines in cold property Current trends and patterns of female migration: evidence from Mexico. The application of two synthetic oligonucleotides as probes and as primers in the polymerase chain reaction is presented for a specific, sensitive, and quick identification of Brucella spp.

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Mapping the active site of the Haemophilus influenzae methionyl-tRNA formyltransferase: residues important for catalysis and tRNA binding. Interaction of phlorizin and phloretin with glucose transport system of the pigeon intestine. The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. These experiments suggest that guanabenz acts like clonidine in the CNS and that an alpha 2-adrenergic inhibitory mechanism is involved in its myriad of central autonomic effects.

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Problems concerning the mortality data in the 1978 survey are identified and discussed. The ammunition used was a cartridge with a rifled shotgun slug (Brenneke type). Complement is generally recognised as a protective mechanism against the formation of tumours in humans, but is often limited by various resistance mechanisms interfering with its cytotoxic action, now considered as a great barrier of successful antibody-based immunotherapy.

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Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development. Compared to the most widespread absorbent materials such as active carbon, graphene and previously reported supramolecular gel, the proposed CN hydrogel not only exhibited a competitive absorbing capacity (maximum absorbing capacity of methylene blue up to 402 mg/g) but also overcame the typical deficiencies such as poor selectivity and high energy-consuming regeneration. EGF treatment induces a time-dependent decrease in the EGF content in the SMG most likely by reducing the biosynthesis of endogenous EGF. Therefore, we elicit a meta-analysis to investigate the potential value of B7-H3 in the prognostic prediction in human cancers. Both HCMV and EBV significantly diminished the TNF-alpha production typically induced by oral bacteria, inhibited the phagocytic activity of macrophages, and downregulated the expression of toll-like receptor 9.

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We previously determined that members of the retinoblastoma protein family that interacts with the E2F family are differentially expressed and localized in almost all the different cell types and tissues of the testis and in response to known endocrine disruptors. However, the RWV is able to reproduce in a controlled fashion at least two aspects of disuse that are directly linked, model microgravity and hypoxia.

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Genotyping may also have clinical applications, although it is currently limited to particular scenarios in relation to specific drugs. We conclude that passive diffusion of unmodified PNA is not an effective way of transport into biological cells. The transient PKC activator diC8 had no effect, while studies with the PKC inhibitors sphinganine and H-7 were limited by solvent vehicle cytotoxicity. Four affinity chromatographic steps were required to obtain pure alpha 1-antichymotrypsin. These neurons exhibit distinct activity patterns during the radula retraction phase of motor programs.

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Seventeen of 18 lesions either regressed or resolved since the procedure. Thus, we propose that arsenic trioxide induces topoisomerase I-DNA complexes that participate in chromatin fragmentation and programmed cell death during apoptosis.

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With the same muscle contraction force DNP action was followed by an increase (about 1 1/2-fold) of heat production. Targeting the fibroblast growth factor receptors for the treatment of cancer.

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Detection of density-dependent growth and fecundity of helminths in natural infections. Although long anterior rerouting provides the best tumour exposure along with a low morbidity rate, case-by-case selection of the surgical approach is recommended. Streptozotocin-induced diabetes for 4 weeks resulted in a decrease in proopiomelanocortin (POMC) mRNA in both the anterior lobe (AL) and the neuro-intermediate lobe (NIL) of the rat pituitary. If the MCR-ALS method is to be used with recorded spectral data, the rank deficiency usually present in the data matrix needs to be overcome and the goodness of the results depends on the initial estimates of the chemical species involved in the reaction.

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In vitro culture of human fibroblasts found that the cells could spread on the cellular PCL surface as normal, but showed higher viability compared with the control cells on a flat substrate. In light of the constant emergence of new miRNAs, we further discuss the relative importance of these two functions in evolution. Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers. ATL cells often infiltrate gastrointestinal mucosa and may have triggered CMV gastroenterocolitis in this case. DNA blot analyses suggest that Arabidopsis contains a small RAD21 gene family.

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Every 3 months additional determinations of thyroid hormones and TSH levels were carried out, if necessary, to verify effective TSH suppression. When the tone is presented alone, the entire population of auditory-nerve fibers provides statistically reliable estimates of the 1.0-kHz tone. Histopathological study of aging of the posterior portion of human cervical vertebral bodies and discs--with special reference to the early ossification of the posterior longitudinal ligament Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia.

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Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects. Mid- to long-term outcome comparison of the Medtronic Hancock II and bi-leaflet mechanical aortic valve replacement in patients younger than 60 years of age: a propensity-matched analysis. Vertebral augmentation vs nonsurgical therapy: improved symptoms, improved survival, or neither?

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Fourteen magnetic resonance (MR) images of 11 patients with cerebral sparganosis were reviewed retrospectively and compared with 13 computed tomographic (CT) scans of 10 of the patients. Identification of gastric cancer stem cells using the cell surface marker CD44. Data sources included all Dutch and Swedish drug reimbursement information published in the period January 2005 to July 2011.

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More than 320 kinds of defective congenital conditions were abstracted from hospital records. In 2004, 78 patients underwent carotid endarterectomy in our department, 46 of whom were symptomatic (group A) and 32 were asymptomatic (group B). At the end of the 18 months testing period, LF strips were shipped back to The Netherlands where scan results obtained in South Africa were validated with different UCP scanning equipment including a novel, custom developed, small lightweight UCP strip reader (UCP-Quant), well suited for testing in low resource settings. Drawing from these narratives, recommendations are made to psychologists who seek to subvert the normative silence around class issues and take on the work of providing class-aware services to men and women in poverty.

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The specific binding of the S-tagged leptin to leptin-receptor-expressing cells was further shown by flow cytometry using fluorescence-conjugated S-proteins. Moreover, the NT technique requires donated fresh oocyte, which raises ethical problems for production of human cloned embryo. Serotonin syndrome (SS) is a potentially life-threatening adverse drug reaction that may occur in patients treated with serotonin agonist medications. This effect predominated at low mu receptor occupancy and increased the amplitude of the IPSP.

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Lp(a) may contribute to the increased prevalence of atherosclerotic disease in diabetic patients and patients with chronic renal failure, especially in IDDM patients whose lipoprotein pattern was not different from that of the control group. Dialysis of the PVN with ACSF containing histamine significantly increased the release of OT systemically and centrally within the PVN. Blockage of glyrrhiza uralensis and chelidonium majus in MNNG induced cancer and mutagenesis