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Dutas (Dutasteride)
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Dutasteride

Dutas is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase, an intracellular enzyme that converts testosterone to DHT. Each Dutas soft gelatin capsule, administered orally, contains 0.5 mg of Dutas dissolved in a mixture of mono-di-glycerides of caprylic/capric acid and butylated hydroxytoluene. The inactive excipients in the capsule shell are ferric oxide (yellow), gelatin (from certified BSE-free bovine sources), glycerin, and titanium dioxide. The soft gelatin capsules are printed with edible red ink.

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The results suggest that thyroid enlargement and some alterations in thyroid hormones in bipolar patients may present even before lithium treatment and increase further with lithium treatment. Overexpression of the inhibitory Smad-7 or down-regulation of co-Smad-4 lead to a reversal of the blocking effect of S1P on IL-1beta-induced NO release. Mice homozygous for the disrupted gene display many features common to young human cystic fibrosis patients, including failure to thrive, meconium ileus, alteration of mucous and serous glands, and obstruction of glandlike structures with inspissated eosinophilic material. The skink illustrated an arrangement of primary, secondary, and tertiary septa, with elaborate tertiary septal pits, similar to the amphibian.

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Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation. Phase I trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study. Electrolyte content of blood and bone in chickens subjected to heat stress. This measure consists of 18 questions that examine 12 factors and requires the rater to make a judgement about the likely impact each factor would have on the individual with TBI and significant other.

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A survey was performed over a 3-month period of 617 patients enrolled in 9 exercise-based cardiac rehabilitation centers in New York, Michigan, and Rhode Island. Data from a second survey of 14,274 girls are also used to examine the month in which menarche occurred.

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When used in combination with rhGH, rhIGF-I has a synergistic effect, improving total nitrogen retention in calorically deprived subjects, yet it does not cause any greater enhancement of whole body protein anabolism in normally fed volunteers than giving rhGH and rhIGF-I individually. The intended result would assure sustained affordability and accessibility in breast cancer systemic therapy for patients in low and middle income countries.

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Although performed by a proficient microsurgeon the operative success rate was low, partly because the operation was technically demanding but largely because of the difficulty in assessing intraoperatively the level of occlusion and the quality of the sperm. In patients meeting the inclusion criteria, simultaneous placement of bone grafts and implants shortens treatment time without increasing complications or reducing the success rate. We selected for study 17 normotensive and 12 hypertensive patients with strictly unilateral reflux nephropathy. Neither were the relations between conductance or O2 delivery and O2 consumption affected by indomethacin. Characteristics of frequent users of an acute psychiatric inpatient unit: a five-year study in Portugal.

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The clinical features of status in the remaining 12 patients were in some respects similar to those of the patients with complex partial status. Automated sequential analysis systems for diagnostically relevant clinicochemical parameter combinations.

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Trigeminal ganglia strongly express the mRNA of trkA at E10 and thereafter. Methods necessary to detect pre-existing cardiac abnormalities are discussed to formulate a PPSP for the Medical Commission of the IOC.

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Although the A43 mutant produced significantly smaller lesions in skin of mice than the control, the amounts of virus recovered from the lesions were similar. Correlation between brain tissue and cerebrospinal fluid concentrations of selected compounds in rats with intact and injured blood-brain barrier.

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However, the absolute difference in local failure between the 2 groups was relatively small and therefore does not preclude breast conservation treatment with radiation for triple-negative early-stage invasive breast carcinoma. This review aims to summarize how bacteriophages interact with the oral microbiota, their ability to increase bacterial virulence and mediate the transfer of resistance genes and suggests how bacteriophages can be used as an alternative to the current periodontal disease therapies.

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Based on 6 comparative single-center studies, the FT program was found to reduce length of hospital stay, and was deemed safe for major abdominal surgeries. The relationship of these components with auditory segregation was further investigated using stimuli containing monaural spectral cues to pitch, binaural timing cues to pitch, or a combination of both, interleaved with control stimuli (no pitch). Electron microscopy was valuable in corroborating the results of immunofluorescence. A self-administered questionnaire survey was distributed to targeted hospitals throughout Japan, which were selected using stratified random sampling.

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The leukocytes appear to mediate an oxidative stress, occurring in proximity to nonperfused sinusoids, that may contribute to liver injury. However, these drugs produce aversive effects that could have an important role in the overall acceptability of a drug and its likelihood of being self-administered. Furthermore, we identified a myogenic regulatory factor-related gene Ppa-hlh-1/MyoD and a serum response factor-related gene Ppa-unc-120. Cancer patients who have received at least one dose of epoetin alfa at the NCCS between January 1, 2005 and October 15, 2007 were included in this study. Formation of imine derivatives between tris(hydroxymethyl)-aminomethane and saturated 3-oxo steroids during conventional work up of biological samples dissolved in Tris-HCl buffers.

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Several classes of small molecules have been identified as potent, selective, and efficient inhibitors of the p53-MDM2/X interaction, and many co-crystal structures with the protein are available. Ophthalmic findings among one thousand inhabitants of Rarotonga, Cook Islands. From the nutcracker-phenomenon of the left renal vein to the midline congestion syndrome as a cause of migraine, headache, back and abdominal pain and functional disorders of pelvic organs. The LVP group also smoked significantly more cigarettes than the saline group 4 weeks (p less than 0.05) and 6 weeks (0.01) after the Treatment week.

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To F whether vessels in the ocular fundus changed over the lifetime of Beagles and whether any changes were substantial enough to likely preclude positive identification of individual dogs by use of their retinal vascular patterns. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily. Diagnosis of primary infection was based on the detection of CMV-G, CMV-M and low CMV-G avidity index.

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Noninvasive evaluation of patients with peripheral vascular disease scheduled to undergo surgery: dobutamine stress echocardiography versus myocardial perfusion imaging. Parallel trapping of multiwalled carbon nanotubes with optoelectronic tweezers. The text of this paper is based on a presentation at the First International Congress of Maritime, Tropical, and Hyperbaric Medicine, 4th July 2009, Gdynia, Poland.

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Intellectual capacity and manual dexterity understandably rank highly, but are there minimum thresholds for visual perception that applicants need be able to demonstrate before they enter the profession? Analysing the target protein of the competition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prevention of amyloid toxicity. A versatile method for reconstruction of finger defects: reverse digital artery flap. A METHOD FOR THE DETERMINATION OF DIFFUSION CONSTANTS AND THE CALCULATION OF THE RADIUS AND WEIGHT OF THE HEMOGLOBIN MOLECULE.

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In the present investigation, a pharmacologic approach was used to determine the contribution of the sympathoadrenal system to the exaggerated response. Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. This review discusses the relevant historical aspects, clinical features suggestive of the diagnosis, associated conditions and various appropriate imaging modalities--in particular, trans-thoracic and trans-esophageal echocardiography, Indium-111 radionucleide scintigraphy, and computerized tomographic scanning. Individual pulse energies ranged between 10 and 135 millijoules. It also estimates the most suitable amplitude of functional movements.

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The effect of different factors (host sex, sampling site, and time) on nematode counts and aggregation were analyzed and discussed considering the peculiarities of the study site and the chamois population crash. In 64 patients with confirmed subarachnoid haemorrhage the clinical grading according to Hunt and Hess was compared to the initial findings of BAEP und SEP to elicit possible prognostic statements. The primary goal of medical and nursing management in the traumatic brain-injured patient is to decrease intracranial pressure (ICP) and maintain adequate cerebral perfusion pressure (CPP). Circulating angiotensins in the river lamprey, Lampetra fluviatilis, acclimated to freshwater and seawater: possible involvement in the regulation of drinking.

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Treatment of rats with ginkgolide B (GKB), specifically reduced the ligand binding capacity, protein, and mRNA expression of the adrenocortical PBR and circulating glucocorticoid levels. This single center study was designed to evaluate the efficacy of the VelaSmooth versus TriActive in the reduction of the appearance of cellulite. EBCT can be used for reproducible quantitation of aortic valve calcification. The cells showed no diminution in growth as a function of in vitro age.

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First and second generation antipsychotics differentially affect structural and functional properties of rat hippocampal neuron synapses. Kids born on the farm during October acquired their first nematode infections between 2 and 3 months of age and the intensity of infection increased erratically thereafter to reach a plateau once the kids were 14 months of age.

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However, few studies have examined the treatment response of Hispanics to combination therapy with pegylated interferon and ribavirin. The significant associations of certain SOCS3 polymorphisms with obesity parameters in both MS and MS -related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of MS and also that they can be potentially used as a marker for attenuated or aggressive disease. Chimeric molecules between human lipoprotein lipase (LPL) and rat hepatic lipase (HL) were used to identify structural elements responsible for functional differences.

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Dysregulated Erythropoietin, Hepcidin, and Bone Marrow Iron Metabolism Contribute to Interferon-Induced Anemia in Hepatitis C. 52 patients were divided into 2 groups: Group 1 (controls) consisted of 31 patients who underwent elective (PTCA) and group 2 of 21 patients who underwent emergency PTCA for unstable angina or acute infarction. It is based on a combination of quantum-chemical DFT calculations and quantitative solid-state NMR measurements of N-H and H-H distances.

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They do not fix complement and cannot be detected by standard immunoprecipitin assays. Some strains within a cluster showed identical ribotype patterns with both endonucleases (A. Only patients with non-infectious non-anterior uveitis and without systemic features were selected. Vinblastine in the treatment of children and adolescents with refractory immune thrombocytopenia. Allergy to fresh fruits and vegetables is mostly observed in subjects with pollinosis, especially from birch, because of cross-reacting allergens in vegetable foods and pollens.

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Mouse monoclonal antibodies (MAbs) specific for the lipopolysaccharide (LPS) core types R1, R2, and R3 of Escherichia coli and a cross-reactive MAb that binds to the LPS core of almost all E. This review does not cover the relative efficacy of lithium compared with other maintenance treatments, which is at present unclear. Left-ventricular assist device implantation (LVAD) is still associated with thromboembolism as the optimal anticoagulation is still unclear. Closing address of the President of the Mexican Association of Gastroenterology The parental origin of alleles could be determined at two other loci in the hybrid cells.

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The phagocytotic process in the sperm of the tick Hyalomma dromedarii (Acari: Ixodidae). Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and many induce apoptosis via generation of reactive oxygen species (ROS). Women with late onset of menopause had longer and more variable cycles in the premenopausal interval than did those with early onset. The medial division of the medial geniculate body (MGm) projects to the lateral amygdala and the upper layer of auditory cortex and develops physiological plasticity rapidly during classical conditioning.

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The cost effectiveness of state EITC supplements was estimated using a microsimulation model, which was run in 2015. Regardless of stability or imaging conditions, the paramagnetic starch particles investigated showed potential as negative liver contrast enhancers. Additionally, over-expressions of NADPH oxidase p22, p47, p67 subunits and the ET pathway were significant in the diabetic testis relative to normal and were completely abolished by FDP-Sr. Thus, the results demonstrated that in vivo efficacy of anti-MM46 conjugate over anti-MM46 IgG alone by therapeutic experiments as well as by tumor-neutralizing assay and suggested the potential use of monoclonal antibody-cytotoxic agent conjugates in cancer therapy.

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The surface of human menisci and its aging alterations during age. These findings and the previous observations that neutrophils in the circulating and marginal pools have high NAP activity and neutrophils in the bone marrow pool have low NAP activity taken together suggest that, following initial administration of rhG-CSF, functionally active neutrophils leave the bloodstream preferentially, which is primarily followed by an influx of neutrophils from the bone marrow, but not by demargination of sequestered neutrophils. Apoplastic guaiacol peroxidase (POD) and symplastic ascorbate peroxidase (APX) activities were induced in leaves of E. The low density lipoprotein receptor-related protein (LRP) is a multifunctional endocytic receptor with the ability to bind and endocytose several structurally and functionally distinct ligands. The impact of self-regulation ability and possible unspecific effects still require further investigation.

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They arise before gross topographical enlargement and may serve as a predictor of ventricular dilatation. Earlier studies had shown that the rat does not require olfactory cues to perform efficiently in radial mazes. The purpose of this investigation was to attempt to image extracted human teeth with the aim of establishing the possible future application of magnetic resonance imaging in the diagnosis of pulpal pathosis. This modification reduced the affinity 3-fold but yielded near-maximal efficacy.

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Method development for aquatic ecotoxicological characterization factor calculation for hydrocarbon mixtures in life cycle assessment. A network approach to the systematic analysis of yeast gene function. The total number of all adrenocortical cells increased from ca 13 million on day 21 to ca 25 million on day 77 and at all intervals studied adrenal glands of male and female rats contained a similar number of parenchymal cells. Adriamycin is a potent chemotherapeutic agent used in the treatment of human neoplastic diseases. Intradermal skin tests (IDSTs) were performed on 65 atopic and 24 normal dogs.

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For the early detection of lung cancer at a stage when it is localized and hence resectable, persons in a high-risk group should be screened periodically with sputum cytologic studies and chest radiographs. Electric field ionization of high Rydberg states of Ar with sequences of identical pulses.

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The ATP binding cassette (ABC) transporter protein Yor1p was identified on the basis of its ability to elevate oligomycin resistance when it was overproduced from a high-copy-number plasmid. EMG biofeedback in the treatment of hyperfunctional voice disorders. GC-MS/MS measurement of natural and synthetic estrogens in receiving waters and mussels close to a raw sewage ocean outfall.

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Comparison of the performance of 6- or 30-night extended wear schedules with silicone hydrogel lenses over 3 years. Mental health in American colleges and universities: variation across student subgroups and across campuses. Variables recorded were age, sex, physical status, history of alcoholism or addiction to injected drugs, associated disease (liver disease, chronic kidney failure and hemodialysis, and coagulation disorders), history of blood products transfusion, preoperative liver enzymes and blood levels of AcVHC and AgVHB as determined by enzyme immunoassay.

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Two hundred and thirty-seven community-dwelling adults aged 60 years or more with one or more of arthritis (osteoarthritis or rheumatoid arthritis), chronic obstructive pulmonary disease, diabetes or heart disease completed a cross-sectional, mailed survey. A review of the unique physiologic requirements for a successful extended wear lens and how the first and current SiHy lenses address them is provided. Making the organization of rehabilitation more efficient, emphasizing early start of rehabilitation, and close cooperation between the involved health professionals and an improvement of their competence have the best documented effect on mortality and on the percentage of patients who return home.

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In 8 districts of Odisha, popularly known as the Kalahandi-Balangir-Koraput (KBK) region which is notable for extreme poverty and starvation deaths, the government did away with the targeted food assistance program in 2008 and made the scheme universal. A comparison of two delivery methods on the bronchodilator effects of beta 2-stimulant We believe that a combination of any two of the above three risk factors may prove to be a reliable marker of inflicted head injury in children admitted to a pediatric ICU and will lead to an early and definitive diagnosis. Comparative performance of playground surfacing materials including conditions of extreme non-compliance.

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