Grisetin is an antibiotic produced by Penicillium griseofulvum. It has selective fungistatic activity against the dermatophytes that cause ringworm (tinea) infections, but it has no activity against pityriasis (tinea) versicolor or Candida spp. It acts by disrupting the mitotic apparatus of fungal cells, thereby inhibiting protein synthesis. Grisetin is efficiently absorbed after oral administration, particularly when taken with fatty foods. It has a plasma half-life of 24 hours and is extensively metabolized in the liver. About 50% is excreted in the urine, largely as metabolites, within 5 days. Much of the remainder is selectively bound in keratin precursor cells, particularly in infected areas.
Other names for this medication:
Griseofulvin,
Grifulvin,
Fulcin,
Fulvicin,
Fulviderm,
Fungistop,
Grifulin,
Grisetin,
Griseofulvina,
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Motivan,
Cotrimstada,
Zitrim,
Topamax,
Nefazan,
Doneurin,
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Riazole,
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