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Lamisil (Terbinafine)
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Terbinafine

Lamisil is a synthetic allylamine derivative that has potent activity against many dermatophytes that affect skin and nails, including Epidermophyton floccosum, Trichophyton mentagrophytes and Trichophyton rubrum. The antifungal activity of Lamisil is believed to be due to the selective inhibition of fungal squalene epoxidase, which increases squalene to toxic levels, thus killing the fungal cell. Lamisil was approved for use in the United States in a topical form in 1992 and as an oral antifungal agent in 1998. Topical Lamisil is available over-the-counter as a 1% cream or spray for treatment of dermatophyte infections of the skin (tinea pedis, cruris or corporis). Oral Lamisil is available by prescription only in tablets of 250 mg generically and under the brand name of Lamisal. Oral Lamisil is used in the therapy of onychomycosis or fungal infections of the fingernails or toenails (tinea unguium) typically in a dose of 250 mg once daily for 6 weeks (fingernails) or 12 weeks (toenails). The most common side effects of Lamisil include gastrointestinal disturbances, headache, change in taste and rash.

Other names for this medication:
Terbinafine, Lamisil,

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Accumulation of macrophages in brain tissue as observed in nervous system injury may be due to local production of hematopoietic colony-stimulating factors (CSF). The activity of 72 1,4-dihydropyridines as calcium channel antagonists was examined. Complete medium from melanoma cell cultures stimulated fibroblast hyaluronate synthesis 9.3-fold, and sulphated GAG synthesis 2.6-fold, as measured by 3H-glucosamine incorporation.

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