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Orifungal (Ketoconazole)
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Ketoconazole

Orifungal is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Orifungal against these fungi and are safer. Thus, Orifungal remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Orifungal is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Orifungal is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Orifungal has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Synthesis and anticholinergic activity of N-alkyl 1- and 2-diarylmethylene-indolizidinium bromides. We predict that this disruption of cell division results in daughter cells being deposited in the lamina propria where their population expands and partially differentiates, resulting in the formation of foci of signet ring cells. Glucocorticoids are representative agents in the anti-inflammatory treatment of allergic airway diseases. In this commentary, we describe the factors associated with inappropriate antibiotic prescriptions in hospital, outpatient, and long-term care settings, along with specific measures that can help prevent antibiotic misuse.

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Triplet entropy analysis of hemagglutinin and neuraminidase sequences measures influenza virus phylodynamics. This acute manifestation is not likely to be a simple consequence of reduced dopaminergic activity, because it was never reported to occur following the use of drugs which deplete dopamine stores, like reserpine and tetrabenazine. Study of microbial community of brewery-treating granular sludge by denaturing gradient gel electrophoresis of 16S rRNA gene. Misexpression of the white (w) gene triggers male-male courtship in Drosophila. A large male employee population with continuous low level work exposures to methylene chloride for up to 30 years was examined for mortality experience using non-concurrent prospective and proportionate mortality techniques.

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Sonographic evaluation of deep endometriosis: protocol for a US radiology practice. An inactivation model consistent with these observations was found to provide adequate representation for the free chlorine inactivation of adenovirus serotype 2 as well as that reported in the literature for other adenovirus serotypes. This study examined a possible association of dietary exposure to polybrominated biphenyls (PBBs), a brominated flame retardant, and self-reported abnormal Pap test results and cervical dysplasia as a precursor to cervical cancer. Examination of the detached cells by fluorescence microscopy after staining with acridine orange or by electron microscopy revealed evidence of chromatin condensation and margination. Synthesis of the 25 kDa protein was blocked by phosphonoacetic acid, an inhibitor of DNA synthesis, indicating that the UL4 gene is expressed with gamma kinetics.

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Treatment of internal iliac artery aneurysms: single-centre experience. This article discusses a female condom that offers Zambian women another option to control their own fertility and sexual health. The clinical benefit of BGM complex formulated in a cream was assessed in subjects prone to acne through sebum composition analysis and photometric assessments.

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The vessels of the branchial circulation of the Atlantic hagfish, Myxine glutinosa, and their relationship with the gill epithelia have been studied by light and electron microscopy. We conducted a cross-sectional study of 300 SSc outpatients with and without LVDD, seen between May 2012 and May 2014, and performed univariate and multivariate regression analyses to determine clinical factors associated with LVDD. To identify in vitro the leakage sites by atomoxetine dosage forms of seroquel bubble test and to measure the leakage rate by the increased oxygen (O2) flow needed to maintain the circuit pressure provided by an anesthesia machine previously verified to have no leaks.

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