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The winged helix-turn-helix model for the repair of O6-MeG to guanine involving the reaction of O6-MeG with a tyrosine residue of the protein O6-alkylguanine-DNA alkyltransferase (AGT) was examined by studying the reaction mechanism and barrier energies. Indeed, statins increased the human apoA-I promoter activity in transfected cells, and we have identified a statin response element that coincides with a PPARalpha response element known to confer fibrate responsiveness to this gene. Sonographic demonstration of endometrial fluid collection following termination of pregnancy. Australian and New Zealand Clinical Trial Registry ACTRN 12611001107910.

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The patient was then successfully given liposomal amphotericin B (3 mg/kg/d for 10 days). We identify the N-terminal SH3-BH region of p85alpha, absent in the smaller p55alpha and p50alpha isoforms, as the region that mediates PTEN binding and regulation. The clinical diagnosis of any skin tumour undergoing surgical removal was compared with the final histopathological diagnosis. According to this experiment there is no possibility of inflow of proteoglycan from the annulus into the notochordal nucleus.

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Regional differences in lectin binding to colonic epithelium by fluorescent and electron microscopy. We speculate that the impact of p.L245F on BRAF protein function differs either qualitatively or quantitatively from those mutations associated with CFCS.

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One-step immunoaffinity purification of complex I subunits from beef heart mitochondria. Different cytokines and chemicals can be used to modulate this osteogenic response. Statistical analysis of the errors in the depth and flux of the reconstructed inclusions and the convergence time of the proposed method is used to demonstrate its unbiased performance, low error variance, and computational efficiency. Among the compounds, 2-oxoSCA produced the most changes and 2-phenylSCA produced the least, none. Using survival analysis, we assessed primary and secondary patency, and identified predictive factors taking into account competing risks.

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To determine whether the marks in the third year Objective Structured Clinical Examination (OSCE) were affected by the collusion reported by the students themselves on an electronic discussion board. (2) The addition of a radiosensitive promoter to lipid nanoparticles was sufficient to confer radioisotope-activated expression of the genes delivered by the nanoparticles. Because animals, in particular domesticated livestock, are its primary host, human infection is usually zoonotic.

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To demonstrate the ability of our technique, we analysed two systems: (i) interactions of the fluorescent dye Rhodamine 110 inside and outside of a glutathione sepharose bead, and (ii) microtubule dynamics in live yeast cells of Schizosaccharomyces pombe using a fusion protein of Green Fluorescent Protein (GFP) with Minichromosome Altered Loss Protein 3 (Mal3), which is involved in the dynamic cycle of polymerising and depolymerising microtubules. Compared with the Hans, Uygurs had a lower MBP-54 mutation rate. Differential perinatal testosterone secretory capacity of wild house mice testes is related to aggressiveness in adulthood. This manuscript describes the rationale, design and methodology of Health Is Power (HIP), a transcultural, community based, randomized controlled trial that investigated the effectiveness of a group cohesion intervention to increase physical activity and improve dietary habits in African American and Hispanic or Latina women in Houston and Austin, Texas.

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Furthermore, in so doing, the orientation of the protein is changed from N(out)-C(in) to N(in)-C(out). Some capillaries also penetrate the outer capsule, running into the periaxial space and continuing further towards the polar region. Family disintegration in Latin America: the consequences for children. Loyal patients are sources of repeat business, potential users of new services, and positive spokespersons in word-of-mouth advertising. Effects of ethanol in vitro on rat intestinal brush-border membranes.

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No studies on the relationship between this pharmacological effect and blood levels of the drug have been reported. Rapid UHPLC determination of polyphenols in aqueous infusions of Salvia officinalis L.

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Electrical stimulation in the oculomotor region of the caudate immediately after saccades to a fixed direction led to selective facilitation of saccades in that direction. Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers. Age- and Sex-related Prevalence and Drug Utilization Pattern in the Management of Type 2 Diabetes Mellitus and its Comorbidity with Cardiovascular Diseases: A Comparative Study. Here we explore how their structural and functional properties integrate to regulate muscle development and maintenance. Joint contractures in patients with juvenile diabetes and their siblings.

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In a randomized, crossover, double-blind study, 24-h intragastric pH was measured in 13 H. Efficient use of unlabeled data for protein sequence classification: a comparative study. Calcium metabolism in postmenopausal osteoporotic women is determined by dietary calcium and coffee intake. Molecular changes associated with heat-shock treatment in avian mononuclear and lymphoid lineage cells.

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Cytogenetics in acute lymphoblastic leukemia in Mexican children: an institutional experience. Interference effects and sequential effects could not account for these results. In Study 3, a short (24-item) negative outcome questionnaire was developed to discriminate between concerns about physical and social outcomes. Biochemical tests at Days 6, 13, and 28 showed high amounts of GOT, GPT, LDH, gamma-GTP, and ALP. Studies of the bone marrow which included cytology, histology and electron microscopy failed to reveal why the pelvic marrow was aplastic.

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Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. The author first describes the geographic diffusion of the plague that occurred in the Western Mediterranean in the mid-seventeenth century. We evaluated prospectively the adequacy of medical therapy in 333 consecutive patients undergoing elective coronary arteriography.

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Surgical management of stenosis of the left main coronary artery: invited commentary. Overall, the results demonstrated that an individual difference variable, math anxiety, affects on-line performance in math-related tasks and that this effect is a transitory disruption of working memory.

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The mechanism involved was further investigated by studying the effect of the chelators on uptake of transferrin-bound iron by placental cells in culture. CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma. Continuous monitoring of serum ionized calcium in the dog during sodium citrate infusion using an extracorporeal blood shunt.

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Thirty-three maltreated adolescent females and a comparison group of 112 nonmaltreated female adolescents were administered a questionnaire containing scales measuring locus of control orientation, self-esteem, and depression. The resected liver was maneuvered into a specimen bag and removed. Association of heterotopic neuroglial tissue with an arachnoid cyst in the internal auditory canal.

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A new metastasis model using inoculation sarcomas in adult nude mice after long-term cultivation of sarcoma cells. In 1990, a pilot study was begun that evaluated benign prostatic hyperplasia (BPH) at five clinical institutions. The open-tubular electrochromatographic (OT-CEC) migration behavior of a series of peptides, based on a common structural feature, has been characterized using two different types of chemically modified etched capillaries.

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Effective treatment of alcohol-related steatohepatitis most likely requires dual targeting of oxidative stress and insulin/IGF resistance. Sixteen joints in 12 patients with grafts still in position were followed.

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The hydraulic model was then used to estimate nonpoint loads of selected heavy metals to the sump and to the river. To compare the diagnostic accuracy of contrast-enhanced computed tomography (CE-CT), contrast-enhanced ultrasonography (CE-US), superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI), and gadoxetic acid-enhanced MRI (Gd-EOB-MRI) in the evaluation of colorectal hepatic metastases. Also leu-enkephaline-, peptide histidine isoleusine- and calcitonin gene-related peptide-positive nerve fibers could be observed in all organs, but somatostatin-positive nerves only in the prostate and seminal vesicle and met-enkephalin- and substance P-positive nerves only in the prostate. However, if animals were pretreated with antineutrophil sera prior to APAP administration, neutrophil counts remained depressed, ALT levels were significantly decreased, and the degree of liver injury was attenuated on a histological level. Interleukin 1 (IL-1) induces pleiotropic effects in many cell types during inflammation and immunity.

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The concentration of total identified phenolic acids varied from 93.2 to 453.8 mg/kg in the shoots of 58 accessions. Hepatitis C infection: A multi-faceted systemic disease with clinical, patient reported and economic consequences. First described by Weber and later modified by Fergusson, the Weber-Fergusson incision has undergone numerous modifications, but the fundamental approach to maxillectomy has largely remained the same.

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A recent study using a transgenic mouse, whose intestinal mucus contains a molecule made of 12 copies of a domain found in many gelling mucins, demonstrates that it is possible to strengthen mucus properties in situ, leading to promising new treatment strategies in diseases in which the mucosal barrier is impaired. This patient, a 62-year-old female, with squamous cell carcinoma of the lung was inoperable because of poor pulmonary function due to severe bronchial stenosis by a tumor at the orifice of the right main bronchus. Validity criteria for local thermodynamic equilibrium in plasma spectroscopy.

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Based on this study, race/ethnicity is not an independent risk factor for poor prognosis in women diagnosed with invasive vulvar cancer, despite differences in treatment modality by race/ethnicity. The method is an effective means to combine spatial information with DVH metrics and provides a practical means of specifying the location of dose features with respect other structures in the treatment plan. An inverse relation between EZH2 and DLC1 expression was observed in the liver, lung, breast, prostate, and ovarian cancer tissues. Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer. Our results suggest that PKCalpha and PKCdelta play opposite roles in the proliferation and apoptosis of glioma cells.

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William Harvey, MD, FRCP (1578-1657) and the historic development of the circulation of the blood. Cats have an excellent outcome and dogs a very good outcome following surgery for corneal and lens laceration. The cholesterol-lowering effect of the unicellular green alga Scenedesmus acutus 276-3a. Reducing vertical key spacing from 19 to 17 mm had no significant effect on productivity or usability ratings.

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The rate of caesarean sections is increasing worldwide, yet medical literature informing women with uncomplicated pregnancies about relative risks and benefits of elective caesarean section (CS) compared with vaginal delivery (VD) remains scarce. We conclude that gliadin is capable of inducing HLA-DR on the crypt epithelium of in vitro cultured coeliac disease mucosa, providing indirect evidence that gliadin may activate cell mediated immune mechanisms within the small bowel mucosa.

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New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. The first domain, TA1, is contained within the last 30 amino acids of p65, whereas TA2 comprises the adjacent 90 amino acids. Members of the American Pediatric Surgical Association (APSA) were surveyed. In the yeast Saccharomyces cerevisiae, the switch from respiratory metabolism to fermentation causes rapid decay of transcripts encoding proteins uniquely required for aerobic metabolism. A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry.

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The approach provides increased BMD precision for effective potency rankings across compounds and other covariates that pertain to a hypothesised mode of action (MOA). Prevalence and putative risk markers of challenging behavior in students with intellectual disabilities. Secondary analysis of data collected in junior and senior high school surveys in Alberta, Canada.

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The amplitude and latency of somatosensory evoked potentials (SEPs) in healthy subjects depend on intensity of stimulation. Spasmodic dysphonia (SD) is a task-specific focal dystonia of unknown pathophysiology, characterized by involuntary spasms in the laryngeal muscles during speaking.

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To answer the question whether the TSI (tissue strain imaging) sonoelastography technique can contribute to the diagnosis of chronic renal allograft damage. The association of thrombosis with an abdomino-pelvic mass should suggest that there is a malignant tumour present, and aetiology must be explored. Prevalence of goiter was relatively high and therefore constituted a public health problem in this region. An analysis of the correlation between tumorigenicity and the loss of expression of the large external transformation-sensitive glycoprotein (LETS) was performed on human cell hybrids and their respective normal and tumorigenic parental cell lines.

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. Enzyme characteristics have been correlated with the nucleotide synthesis achieved in intact cells incubated in suitable mediums containing (14-C)-nicotinate or adenine.

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A predictive model for remission and low disease activity in patients with established rheumatoid arthritis receiving TNF blockers. These results suggest that p60c-src is important in osteoclastic bone resorption. Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells. In vitro differentiation of trout oligodendrocytes: evidence for an A2B5-positive origin. Their role in this attachment, however, has not been established and further work is needed to examine their interaction with actin and to identify any other components with which they may interact, particularly in the plasma membrane.

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Preserved hyperaemic response in (distal) string sign left internal mammary artery grafts. In vitro studies on the self-differentiating capacities of the post-nodal pieces of definitive primitive streak treated with uridine.

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Vesicovaginal reflux is a common cause of urinary incontinence in girls. Flow cytometric and immunohistochemical analyses indicated that enhanced induction of apoptotic cell death, cell cycle arrest in G(0)/G(1) phase, and ductal epithelial differentiation are involved. We also examined the effect of apocynin in vivo, and the results showed that in SAMP6 mice, bone mineral density and total bone volume were increased after 3 months of apocynin treatment. One of the interesting byproducts of that study was the possibility that verapamil prevented postinfarct sudden death, which implies a potential antiarrhythmic mechanism. The program accounts for LD structure of different populations so that a GWAS study from one ethnic group can be used to choose SNPs for one or more other ethnic groups.

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We have identified Cdc55, a regulatory B subunit of protein phosphatase 2A (PP2A), as an essential activating factor for stress gene transcription in Saccharomyces cerevisiae. They deal with the refined ultrastructure of the NE and NPC, with the discovery of novel NE components, and, importantly, with novel roles and fates of NE-associated and NPC-associated proteins during plant mitosis and cytokinesis. This paper examines the potential links between growth of income/head and population growth during demographic transition.

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We found a significant difference only after 60 min of perfusion at which time important lesions appeared in the cornea of eyes perfused with physiological saline. Image-based approaches to single-cell transcriptomics, in which RNA species are identified and counted in situ via imaging, have emerged as a powerful complement to single-cell methods based on RNA sequencing of dissociated cells. This study questions previous reports of the presence of micrometer-sized areas of crystalline silica in pathologic tissue sections that are based exclusively on polarized-light microscopy.

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An eleven year follow-up of delayed-type hypersensitivity testing for the identification of HIV-1 infected patients at increased risk of developing AIDS. This difference cannot be explained by life history, social behaviour or brain size. Making connections: the linkage between research and practice--evidence for improving the quality of pediatric nursing.

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These results are important for the understanding of some pathomorphological and pathophysiological reactions of skin compartments of man. The adoption of specific neurotransmitter phenotypes is crucial for the progression of neuronal differentiation, enabling neurons to connect with each other and with target tissues. Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex. NIH3T3 are the only cells so far tested that have detectable XD and xanthine oxidase activities under basal conditions and after IFN-alpha A/D treatment, although their responsiveness to the cytokine is much less than that observed in L929 cells.

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Bacteria isolated from internal organs of infected fish were biochemically homogeneous and identified as Vibrio parahaemolyticus. Goal of study was to test formulas for catheterizations of internal jugular veins (IJVs) in a population of different body height classes with correct CVC tip positions. A further 13 cases from eight Arab families of different nationalities were ascertained among referral cases.