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To evaluate the influence of sex and CYP2D6 genotype on mirtazapine disposition within two bioequivalence studies in healthy volunteers. We used two alternative techniques of dye loading to examine the changes of intracellular calcium induced in rat osteoclasts by three stimuli. It also overcomes technical limitations inherent in the first-generation interventional MRI system.

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Bioconversion of arachidonic acid by human uterine cervical tissue and endocervix in late pregnancy. We then investigated the efficacy of MTX and the serum FA levels in these patients. Two cases of primary invasive cutaneous infections caused by the zoophilic dermatophytic species Microsporum canis are presented. Consequently there is a need for a technique that overcomes the failures of project-level EA, LCA and CBA, and assesses total environmental risk.

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The rickets healed with physiological doses of 1-alpha-hydroxy-cholecalciferol. Small bimetallic (Pt/Pd) particles by biosynthesis: transmission electron microscopy and quantum mechanical analysis.

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Linear regression analysis was used to evaluate the relationship between IOP measurements and CCT. However, when TSH levels were increased through low-iodine chow and sodium perchlorate, the induced goiter was more prominent in caveolin-1 knockout mice. Development and use of a computer program for analysis of data concerning delivery Based on experimental data we offer the theory that during early learning events (also termed as imprinting) the initially relatively unspecifically organized synaptic network in the higher associative brain areas undergoes an experience- and learning-dependent reorganization.

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Hemodynamic and endocrine changes associated with hypotensive action of amosulalol in essential hypertension. The Yamazaki strain was isolated from a patient of tsutsugamushi disease and the other strains from wild rodents (Apodemus speciosus). That is, only two distinct populations can explain both equilibrium and kinetic measurements. In addition, all adaA positive strains in humans and animals showed the occurrence of the QpH1 plasmid.

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To describe the clinical features of members of a family with acorea, microphthalmia and cataract syndrome. Cytoplasmic actin in neuronal processes as a possible mediator of synaptic plasticity.

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The development of high-performance leukodepletion blood filters and of low-leukocyte plateletapheresis machines has provided the technology to reduce recipient exposure to allogeneic donor leukocytes. We have adapted the streptomycin-treated murine model of chronic mucosal colonization by enteric pathogens to study colonization by P.

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Pharmacokinetics of chlordiazepoxide and metabolites following single and multiple oral doses. We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2. The stability of receptors from the two species differed significantly, the chick receptor being more stable. Real-ear calibration of ipsilateral acoustic reflex stimuli from five types of impedance meter.

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The mouse homologue of the tuberin gene (TSC2) maps to a conserved synteny group between mouse chromosome 17 and human 16p13.3. Male functions and malfunctions: the impact of phosphoinositides on pollen development and pollen tube growth. Various methods of generating practice protocols for the nurse-managed center are outlined.

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Postoperative imaging studies showed stable constructs in 4 patients.The use of expandable cages in multilevel corpectomies for the treatment of metastatic cervical spine disease appears to be a safe and effective way to reconstruct the anterior column of the cervical spine, preventing further neurologic deterioration. All patients received at least 30 days of follow-up until definitive diagnosis of malignancy was established or 1-year follow-up if index tissue sampling was benign. Sixteen hundred and seventy-seven melanoma patients were treated at Duke University Medical Center from 1956 to 1976.

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Identification of markers to predict subsequent ICD therapy and symptoms after the first event could affect patient management. Herpes simplex virus 1 (HSV1) is a widespread virus that primarily causes orofacial infection. Our results suggest that the role of activated microglia in astrogliotic processes following injury of the brain has to be reevaluated, as microglia in their activated state might support the onset of astrogliosis on the one hand, but might delay or reduce subsequent glial scar formation on the other hand. These strains released CO2 significantly from the methoxyl group and transformed the other carbons from the phenylpropane skeleton of lignin also into CO2.

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In this perspective, we discuss the prospects for robotics and automation to influence neuroscientific and intact-system biology fields. R-Smads are phosphorylated by type I serine-threonine kinase receptors for TGF-beta superfamily members. Several of these genotyping strategies have been shown to have substantial impact on therapeutic outcome and should eventually lead to improved anticancer chemotherapy. Tamoxifen treatment of metastatic breast cancer and antithrombin III levels.

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The effect was further augmented when pGH was given together with PS-7.6 antibody and the enhancing ability of the antibody lasted beyond the treatment period. Structure and morphogenesis of the uterus, placenta, and paraplacental organs of the neotropical disc-winged bat Thyroptera tricolor spix (Microchiroptera: Thyropteridae). Comparative tolerability and efficacy of treatments for impotence. The formation of ReS(2) inorganic fullerene-like structures containing Re(4) parallelogram units and metal-metal bonds.

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Both viruses have circular, double-stranded DNA genomes of 38,049 bp for APSV1 and 13,769 bp for APOV1. The parasite was able to efficiently bind and penetrate human dermal fibroblasts, human laryngeal epithelium, and human umbilical vein endothelial cells. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. Analyses revealed that major and minor stress were significant predictors of all measured domains of quality of life, even after age and number of chronic illnesses were statistically controlled.

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Transitions between tobacco and cannabis use among adolescents: a multi-state modeling of progression from onset to daily use. The predicted EDS1 carboxyl terminus has no significant sequence homologies, although analysis of eight defective eds1 alleles reveals it to be essential for EDS1 function. This article discusses the higher risk of patients with diabetes, the data comparing surgery and angioplasty and outlines the advances in angioplasty since BARI.

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The presence of a butterfly rash is generally a sign of lupus erythematosus (LE), but it can also include a plethora of conditions. Australian and New Zealand Clinical Trials Registry (ACTRN12607000441415). Measured were glare sensitivity and visual acuity at 3 contrast levels using the Opthimus Y-VA Contrast Sensitivity Test and Glare Test.

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Images were reviewed by 3 musculoskeletal radiologists, and consensus was determined on the presence of increased signal in the rotator interval area. A means is shown to modify a gas chromatograph for this type of analysis. Immunonutrition also acts with the healing process, in particular with arginine, which promotes collagen synthesis. Cumulative toxicity potential of methomyl aerosol by repeated inhalation.

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The solution structure of Cu(I)-CopK demonstrates that Cu(I) binding induces a complete structural modification with the disruption of the second beta-sheet and a rotation of the C-terminal part of nearly 180 degrees around a hinge formed by asparagine 57. Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung. The majority of these tumours are located superficially (in subcutaneous tissue) and occur in the proximal parts of the extremities. The peptide motif ProXaaArg/Lys (PXR/K), which is recognized by a PXR/K-specific GalNAc-transferase, is present in each of these glycoproteins 6-9 residues NH2-terminal to an Asn glycosylation site. The presence of the indanyl-glycine moiety gives delapril a high lipophilicity, greater than several other angiotensin-converting enzyme (ACE) inhibitors, such as captopril and enalapril.

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Here we use a modified yeast one-hybrid assay to isolate a B-cell factor, Bob1, which associates with either Oct-2 or Oct-1. To determine the prevalence and maternal and neonatal outcomes among women with major placenta previa (PP). Perhaps the most challenging of these is to understand the mechanisms which underlie the complex relationship between genotype and phenotype.

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Career tracking data indicated that nearly half of the new investigator participants published their work in peer-reviewed journals, and about one third were successful in obtaining research funding. Experimental study using real-time polymerase chain reaction and in situ hybridization. It is linked to cognitive performance arguing against distinguishable diagnostic subtypes. Water-in-oil droplets can be charged on generation by synchronized electrostatic actuation.

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Acquired personality disturbances associated with bilateral damage to the ventromedial prefrontal region. The PNH-like cells which better mimicked true PNH were those prepared using acetylcysteine. In addition, prolactin and growth hormone secretion patterns were assessed. This combination of findings may represent a new syndrome or another expression of frontonasal dysplasia.

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By means of transesophageal echocardiography it is now possible to assess and to monitor left ventricular function during anesthesia and surgery. Thymomas are present in 30 percent of myasthenic patients over age 40.

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Of those, 23 patients had multiple pure GGOs on their preoperative computed tomography (CT) scans. Heterophyiasis is an important food-borne parasitic zoonosis in Egypt, among the inhabitants living around brackish-water lakes especially fishermen, and it is a common human parasite in the Nile Delta. The investigation and management of two patients with pulsatile masses are described. Adenosine diphophate (ADP) and collagen-induced platelet aggregation and ATP release were evaluated before and after oxygenation in groups 1 and 2.

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Estimates for 15 individual rate constants have been obtained for this model by numeric simulations of the various time courses. Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci. Other helminthic infections: Ascariasis, Dracontiasis, Lagochilascariasis, Micronemiasis.

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2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. Several simulation scenarios are executed in the pitch and yaw channels to evaluate the controller performance. The histamine-induced contractions and the relaxing effect of histamine on the potassium chloride (39 mmol/L) contractions were studied in relation to the existence of endothelium, L-NG-nitro arginine, and indomethacin. Controlling implosion symmetry around a deuterium-tritium target.

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The control group consisted of 107 siblings of the diabetics and of 107 other healthy children of corresponding age groups. There is evidence that TO is a risk factor in the progression of IPD. Translation and validation of the traditional Chinese version of the faecal incontinence quality of life scale. In addition, an animated clay model was constructed to identify and quantify tissue movement seen during the processing of Mohs surgical specimens. The interval from injury to presentation was between 1 and 96 hours.

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All demographic data in the two treatment groups were comparable. Microtubule-associated protein 5-like immunoreactivity was reduced in neuronal perikarya and neuropil four days to two weeks after injury. Although the survivors report problems, the overall HRQOL after Tx is good. It is evident from the literature survey that red mud has been found to be efficient for the removal of various aquatic pollutants, especially arsenic and phosphate.

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Studies on the chemical constituents of Atalantia buxifolia (Poir.) Oliv Connecting the anterior archwire with the posterior elements by means of a steel ligature can be recommended only in some cases, because sagittally directed forces may be produced. With increased use of human otologic homograft tissue for implantation, different preservation techniques and products are used for storing and preserving the grafts before surgery. Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma.

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For a reliable interpretation of left-right difference in Vestibular evoked myogenic potential (VEMP), the amount of sternocleidomastoid muscle (SCM) contraction has to be considered. 3 women and 2 men, aged 46 (22-69) years when they sustained a radial neck Mason type IIIb fracture, were evaluated after an average of 18 (16-21) years.

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Several parsers and editors of KEGG pathways exist for processing KGML files. Cells from the tissue were also grown as explants and were examined for viruses. A size-exclusion chromatographic method for the simultaneous determination of overall migration and migrating substances below 1000 Da.

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The large size and optical properties of this cell permit observation of cell division processes with great detail in live specimens by simple differential interference contrast (DIC) microscopy. Ocular toxicity due to ethambutol occur infrequently with a dose of 15 mg/kg. Segments of rabbit carotid artery were perfused for 3 hours with nutrient medium to which serum from normal pregnant women or patients with preeclampsia was added.

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The role of the promoter polymorphism (5HTTLPR) of the serotonin transporter gene (SLC6A4) in psychiatric illnesses has been studied extensively. Using a luciferase reporter system, we show that a 43 bp region on the CD5 promoter regulates CD5 expression in resting mouse thymoma EL4 T cells and that an Ets binding site within the 43 bp region mediates the CD5 expression. Muscle electrotransfer covers the delivery of molecules to muscle tissue by means of electric pulses.

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Visual contrast thresholds to both stationary and moving gratings of three spatial frequencies (2, 4, and 16 cyc/deg) were measured over a 32-day period in two women displaying normal menstrual cycles and in two noncycling control subjects. The assay of the complexed (ferrioxamine) and uncomplexed forms of deferoxamine, a strong iron(III) chelating agent, by reversed-phase high-performance liquid chromatography was investigated. Thus, muscle genes with polymorphic CAG/CTG repeats do not appear to play a significant role in the development of NIDDM. In our previous studies, using in vitro cultured embryonic neurons, we demonstrated that MBP (myelin basic protein)-specific encephalitogenic CD4 T-cells induce early neuronal damage. Recently we identified two peptide markers (RA1609 and RT2864) of pancreatic toxicity that are target organ specific.

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This parasite during its development substantially converts hemoglobin into hemozoin. The aim of the paper is to describe a paradigmatic case of a giant kidney angiomyolipoma, not associ- ated with tuberous sclerosis, invading the pelvis and the renal vein. Thus, a significant number of the additional Fugu genes are not the result of the proposed whole-genome duplication in the fish lineage. Recent advances in studies of the molecular basis of endocrine disease.

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Temporal and spatial variation in allocating annual traffic activity across an urban region and implications for air quality assessments. Analysis of a series of human core body temperature illustrates the methodology.